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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Selenium Nanoparticles as Versatile Delivery Tools.

Amir Nasrolahi Shirazi1, Rajesh Vadlapatla1, Ajoy Koomer1

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, Marshall B. Ketchum University, 2575 Yorba Linda Blvd., Fullerton, CA 92831, USA.

Pharmaceutics
|December 31, 2025
PubMed
Summary
This summary is machine-generated.

Selenium nanoparticles (SeNPs) show promise for drug delivery due to their biocompatibility and customizable surfaces. Further research is needed to overcome challenges for clinical application.

Keywords:
anticancer activitydrug deliverymetal nanoparticlesselenium nanoparticles

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Selenium nanoparticles (SeNPs) offer advantages over traditional selenium compounds, including lower toxicity and enhanced bioavailability.
  • Their unique physicochemical properties and intrinsic bioactivity make them suitable for various biomedical applications.
  • Advances in synthesis and functionalization improve SeNP stability, targeting, and circulation time.

Purpose of the Study:

  • To review the synthesis methods, physicochemical properties, and ligand functionalization of SeNPs for drug delivery.
  • To explore the biological activities and therapeutic potential of SeNP-based systems.
  • To identify challenges and future directions for clinical translation of SeNP drug delivery.

Main Methods:

  • Review of current literature on SeNP synthesis (chemical reduction, biosynthesis) and surface functionalization (polymers, peptides, ligands).
  • Analysis of SeNP applications in anticancer, antimicrobial, and anti-inflammatory therapies.
  • Examination of ligand strategies (e.g., RGD peptides, hyaluronic acid) for targeted delivery.

Main Results:

  • SeNPs demonstrate anticancer, antimicrobial, and anti-inflammatory activities, acting as both carriers and therapeutic agents.
  • Surface functionalization enhances receptor-mediated targeting in tumor tissues.
  • Synergistic effects observed with drugs like doxorubicin and paclitaxel.

Conclusions:

  • SeNPs exhibit significant preclinical potential for drug delivery, particularly when functionalized for targeted therapies.
  • Challenges in large-scale production, long-term safety, pharmacokinetics, and regulatory approval hinder clinical translation.
  • Continued research in formulation and in vivo validation is crucial for advancing SeNP-based drug delivery systems.