Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 7, 2026

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

12.2K

Advances in Complement Research: from Pathophysiology to Precision Medicine.

Joshua M Thurman1

  • 1Department of Medicine, Division of Nephrology and Hypertension, University of Colorado School of Medicine, Aurora, Colorado, United States.

Physiology (Bethesda, Md.)
|December 31, 2025
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Complement System01:27

Complement System

9.5K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
9.5K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

911
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
911
Genomics02:02

Genomics

39.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.5K
Complementation Tests00:49

Complementation Tests

6.0K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endothelial cell-released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome.

Science translational medicine·2026
Same author

Activation of platelets and the complement system in mice with <i>Schistosoma</i>-induced pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology·2024
Same author

Alternative pathway diagnostics.

Immunological reviews·2022
Same author

Marginal zone B cells acquire dendritic cell functions by trogocytosis.

Science (New York, N.Y.)·2022
Same author

Natural antibody and complement activation characterize patients with idiopathic nephrotic syndrome.

American journal of physiology. Renal physiology·2021
Same journal

Evolution of Adaptive Non-Shivering Thermogenesis in Mammals.

Physiology (Bethesda, Md.)·2026
Same journal

The Iron Lung: Ferroptosis and Iron Regulation in Aging and Lung Diseases.

Physiology (Bethesda, Md.)·2026
Same journal

RNA-Protein complexes and their role in cell fate.

Physiology (Bethesda, Md.)·2026
Same journal

Ion Channels as Gatekeepers of Fertility: From Uterine Kir7.1 to Sperm CatSper.

Physiology (Bethesda, Md.)·2026
Same journal

Is insulin resistance an adaptive response? Clues from nature.

Physiology (Bethesda, Md.)·2026
Same journal

Physiology in Perspective.

Physiology (Bethesda, Md.)·2026
See all related articles

The complement system, a key part of immunity, protects against pathogens but can cause inflammation in diseases. New drugs targeting complement offer therapeutic potential for various conditions.

Area of Science:

  • Immunology
  • Molecular Biology
  • Biochemistry

Background:

  • The complement cascade is an ancient immune system involving proteins that activate sequentially.
  • It aids in pathogen lysis, immune cell engagement, inflammation regulation, and tissue repair.
  • Intracellular complement protein cleavage also plays roles in homeostasis and signaling.

Purpose of the Study:

  • To review the multifaceted roles of the complement system in host defense and disease.
  • To highlight the significance of complement in autoimmune, inflammatory, and degenerative conditions.
  • To discuss the development and implications of complement inhibitory drugs.

Main Methods:

  • This review synthesizes current knowledge on complement biology.
  • It examines the mechanisms of complement activation and its downstream effects.
Keywords:
autoimmunecomplementinflammationtherapeutics

More Related Videos

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

866
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.1K

Related Experiment Videos

Last Updated: Jan 7, 2026

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

12.2K
Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

866
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.1K
  • It analyzes the therapeutic strategies involving complement inhibition.

    • Main Results:

    • Complement activation is crucial for immunity but can drive pathology when dysregulated.
    • Inappropriate complement activation contributes to a wide range of diseases.
    • Approved complement inhibitory drugs offer targeted immunosuppression.

    Conclusions:

    • The complement system has diverse functions beyond immunity, including tissue repair and cellular homeostasis.
    • Dysregulated complement activation is implicated in numerous inflammatory and autoimmune diseases.
    • Complement biology remains a vital research area with significant therapeutic implications.