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Delayed Onset Unilateral Tongue Edema From ACE Inhibitor-Induced Angioedema
Mizuki Seki1, Saburo Minami1, Takaaki Kobayashi2
1Department of Emergency and Trauma Kameda Medical Center Kamogawa Chiba Japan.
Clinical Case Reports
|January 1, 2026
Summary
Angiotensin-converting enzyme (ACE) inhibitor-induced angioedema can manifest unusually and appear years after starting medication. This highlights the need for vigilance in patients on long-term ACE inhibitor therapy.
Area of Science:
- Pharmacology
- Clinical Medicine
- Immunology
Background:
- Angiotensin-converting enzyme (ACE) inhibitors are widely prescribed for cardiovascular conditions.
- Drug-induced angioedema is a known, albeit uncommon, adverse effect.
- The typical presentation and latency period for ACE inhibitor angioedema are not always observed.
Purpose of the Study:
- To emphasize the potential for atypical presentations of ACE inhibitor-induced angioedema.
- To highlight that this adverse reaction can occur after prolonged ACE inhibitor use.
Main Methods:
- Review of clinical cases and literature.
- Analysis of patient histories and symptom onset relative to ACE inhibitor initiation.
Main Results:
- ACE inhibitor-induced angioedema can present with unusual symptoms.
- A significant delay between ACE inhibitor initiation and angioedema onset is possible, occurring years later.
Conclusions:
- Clinicians should consider ACE inhibitor-induced angioedema in patients presenting with atypical angioedema, regardless of treatment duration.
- Vigilance is required for delayed-onset angioedema in patients on ACE inhibitors.
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