Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.7K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.4K
3.4K
Types of RNA01:20

Types of RNA

8.9K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
8.9K
Types of RNA01:23

Types of RNA

72.4K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
72.4K
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

14.6K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
14.6K
Translational Regulation01:29

Translational Regulation

503
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
503

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accurate prediction of ecDNA in interphase cancer cells using deep neural networks.

Communications biology·2026
Same author

Targeting extrachromosomal DNA in human cancers.

Nature reviews. Drug discovery·2026
Same author

Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D.

Nature communications·2025
Same author

Escape from X inactivation is directly modulated by Xist noncoding RNA.

Nature cell biology·2025
Same author

Genetic elements promote retention of extrachromosomal DNA in cancer cells.

Nature·2025
Same author

Tumour priming by ultrasound mechanogenetics for CAR T therapy.

Nature materials·2025
Same journal

Author Correction: An atlas of genetic effects on cellular composition of the tumor microenvironment.

Nature immunology·2026
Same journal

Exhausted CD8<sup>+</sup> T cell fate is programmed by dynamic CTCF-mediated enhancer activation and invariant CTCF-imposed barriers.

Nature immunology·2026
Same journal

Mapping self-associating chromatin hubs identifies Id proteins as key determinants of exhausted CD8<sup>+</sup> T cell fate.

Nature immunology·2026
Same journal

Exhausted CD8<sup>+</sup> T cell subsets differ a TAD.

Nature immunology·2026
Same journal

Pregnancy-induced tissue-resident memory-like T cells contribute to tumor control in breast cancer.

Nature immunology·2026
Same journal

Mechanosensing by T cells promotes a tissue-resident memory transcriptional program.

Nature immunology·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.3K

Long noncoding RNA regulation of immunity.

Bingfei Yu1,2,3, Howard Y Chang4,5,6

  • 1Department of Immunology and Immune Therapeutics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. bingfeiy@usc.edu.

Nature Immunology
|January 2, 2026
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are key regulators of immune cell function and development. This review details novel lncRNA regulatory mechanisms and their roles in immunity and disease.

More Related Videos

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.1K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

88.1K

Related Experiment Videos

Last Updated: Jan 7, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.3K
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.1K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

88.1K

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) play critical roles in mammalian immunity.
  • Understanding lncRNA regulation of immune cells is crucial for addressing immune-related diseases.

Purpose of the Study:

  • To review recent advancements in understanding how lncRNAs regulate immune cell specification and function.
  • To highlight novel regulatory mechanisms and the role of lncRNAs in immune responses and diseases.

Main Methods:

  • Literature review of recent research on lncRNAs in immunity.
  • Analysis of lncRNA involvement in immune cell development, function, and disease pathogenesis.

Main Results:

  • lncRNAs regulate immune cells through nuclear architecture, chromatin modification, and posttranscriptional control.
  • Emerging mechanisms include metabolic pathway regulation, extracellular ribonucleoprotein complexes, and cell surface glycosylation.
  • Specific lncRNAs control hematopoiesis, immune cell activation, and are implicated in immune diseases, such as female-biased autoimmunity linked to XIST.

Conclusions:

  • lncRNAs are versatile regulators of the immune system with diverse mechanisms of action.
  • Dysregulation of lncRNAs contributes to immune-related diseases.
  • Emerging technologies are rapidly advancing the study of lncRNA biology in immunity.