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Bacteremic versus Non-Bacteremic Urinary Tract Infections: Predictors of Poor Clinical Outcome
Eleni Polyzou1,2, Stamatia Tsoupra1,2, Maria Gavatha1
1Department of Medicine, University of Patras, 26504, Rio, Greece.
Summary
Secondary bacteremia in urinary tract infections (UTIs) significantly increases mortality risk. Early detection and prompt intervention are crucial for improving patient outcomes in these serious infections.
Area of Science:
- Infectious Diseases
- Clinical Medicine
- Microbiology
Background:
- Urinary tract infections (UTIs) contribute significantly to patient morbidity and mortality.
- Limited data exist on the clinical impact of secondary bacteremia in UTI cases.
Purpose of the Study:
- To evaluate the effect of secondary bacteremia on clinical outcomes in hospitalized UTI patients.
- To identify predictors associated with the development of secondary bacteremia.
Main Methods:
- Retrospective, single-center study at a tertiary university hospital.
- Inclusion of hospitalized patients diagnosed with UTIs.
- Analysis of clinical outcomes including surgery, antibiotic changes, and mortality.
Main Results:
- 24.1% of UTI patients developed secondary bacteremia.
- Bacteremia linked to higher CRP, lower hemoglobin, and increased disease severity.
- Hospital-acquired infections predicted bacteremia; bacteremia independently predicted mortality (OR 11.01).
- Multidrug-resistant (MDR) pathogens were a key factor for poor outcomes (aOR: 7.792).
Conclusions:
- Secondary bacteremia is an independent predictor of mortality in UTI patients.
- Antimicrobial resistance surveillance and early intervention are vital.
- Prompt detection and management of bacteremia can improve patient prognosis.
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