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Related Experiment Video

Updated: Jun 14, 2026

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry

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Published on: January 7, 2014

PRE-SURGERY BLOOD CELL RATIOS AND SURVIVAL IN PATIENTS WITH MALIGNANT GLIOMAS.

L Liubich¹, V Rozumenko¹, T Malysheva¹

¹State Institution "Romodanov Neurosurgery Institute, the National Academy of Medical Sciences of Ukraine", Kyiv, Ukraine.

Experimental Oncology

|January 5, 2026

Summary

This summary is machine-generated.

Pre-surgery blood cell ratios like neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) may predict survival outcomes in malignant glioma (MG) patients. Lower NLR and SII values are associated with better relapse-free survival in recurrent gliomas.

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Area of Science:

Neuro-oncology
Inflammatory markers
Cancer prognosis

Background:

Malignant gliomas (MG) are aggressive brain tumors with high recurrence rates.
Prognostic significance of pre-operative inflammatory markers in MG remains controversial.
This study investigates blood cell ratios as potential prognostic factors.

Purpose of the Study:

To assess the relationship between preoperative blood cell ratios and overall survival (OS) and relapse-free survival (RFS) in MG patients.
To evaluate the prognostic value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune-inflammation index (SII).

Main Methods:

Analysis of 59 MG patients (primary and recurrent).
Evaluation of preoperative blood cell counts and ratios (NLR, PLR, MLR, SII).
Kaplan-Meier and Cox regression analyses for OS and RFS.

Main Results:

Elevated peripheral blood leukocytes (PBL), neutrophils (Neu), NLR, and SII in primary and recurrent glioblastoma (GB).
Correlation between PBL, Neu, SII, and tumor grade.
Association of high PLR, NLR, MLR, SII with longer OS in primary tumors, and low values with longer OS in recurrent GB.
Low pre-surgery NLR, SII linked to better RFS in recurrent A-III and GB; low MLR linked to better RFS in recurrent GB.
Sex significantly associated with OS in primary and recurrent GB.

Conclusions:

Preoperative blood cell ratios (PLR, NLR, MLR, SII) show potential prognostic significance in MG patients.
These markers may aid in predicting treatment outcomes for malignant gliomas.