An AIE photosensitizer with type I/II ROS generation for photodynamic therapy of toxoplasmosis
Jiating Chen1, Wen Li2, Rulong Chen1
1Department of Nephrology, The People's Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University, Shenzhen Hospital of Guangdong Provincial People's Hospital, Shenzhen School of Clinical Medicine, Southern Medical University, Shenzhen Baoan Clinical Medical School of Guangdong Medical University, The 8th people's Hospital of Shenzhen, Baoan Clinical Research Center for Kidney Disease, Guangdong 518000, P. R. China. chenjihong0606@hotmail.com.
Abstract:
Toxoplasmosis, a global parasitic disease threatening one-third of humans, lacks effective treatments. We developed a mitochondrion-targeting AIE photosensitizer (AIEPS) generating dual type I/II ROS, enabling light-activated eradication of Toxoplasma gondii and offering a potent photodynamic therapy against toxoplasmosis.
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