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Updated: Jan 13, 2026

Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
Published on: April 11, 2016
Linking Energetic Inefficiency to Ventriculoarterial Uncoupling in Pulmonary Hypertension
Ashwin Venkateshvaran1, Thomas Lindow2,3, Raluca Jumatate4,5
1Department of Diagnostics and Intervention, Clinical Physiology, Umeå University, Umeå, Sweden.
Right ventricular global wasted work (GWW) offers complementary prognostic insights beyond the established TAPSE/sPAP ratio in pulmonary hypertension. Integrating these markers may improve assessment of right ventricular performance in intermediate-risk patients.
Area of Science:
- Cardiology
- Pulmonary Hypertension Research
- Right Ventricular Function
Background:
- Right ventricular-pulmonary arterial (RV-PA) uncoupling is critical for prognosis in precapillary pulmonary hypertension (PH).
- The tricuspid annular plane systolic excursion to systolic pulmonary artery pressure (TAPSE/sPAP) ratio is a recognized bedside marker of RV-PA coupling.
- Three-dimensional (3D)-derived right ventricular (RV) global wasted work (GWW) is a novel energetic marker that may offer additional insights into RV remodeling.
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