Photoredox/Copper Dual-Catalyzed Remote C(sp³)-H Acyloxylation of N-Fluorocarboxamides

We herein disclose the first example of a photoredox/copper dual-catalyzed protocol for the remote C(sp³)-H acyloxylation of N-fluorocarboxamides, employing readily accessible carboxylic acids as acyloxy sources. This methodology demonstrated tolerance for various N-fluoroamides and carboxylic acids, producing structurally diverse functional esters in moderate-to-excellent yields with high site selectivity and chemoselectivity. Moreover, the developed methodology was successfully employed for the late-stage modification of structurally intricate natural products and drugs.