Methanogen Methanosphaera stadtmanae in Women Intestine. Influence on Free Radical Oxidation and Sleep Quality in...

Area of Science:

• Microbiology
• Human Physiology
• Sleep Science

Background:

• Oxidative stress and sleep disturbances are common in menopausal women.
• The gut microbiome, including methanogens like Methanosphaera stadtmanae, may influence host physiology.
• The relationship between M. stadtmanae, oxidative stress markers, and sleep quality requires further investigation.

Purpose of the Study:

• To investigate the correlation between oxidative stress markers, sleep quality, and the presence of Methanosphaera stadtmanae in menopausal women.
• To explore the potential interaction between gut methanogens and oxidative processes in relation to sleep disorders.

Main Methods:

• Assessed oxidative modification products (TBARS, protein oxidation end-products, 8-OHdG, Schiff bases) in 98 menopausal women.
• Utilized the Pittsburgh Sleep Quality Index (PSQI) to evaluate sleep quality.
• Correlated biomarker levels and sleep quality with the presence of M. stadtmanae in the intestine.

Main Results:

• Women with sleep disorders and M. stadtmanae showed higher levels of thiobarbituric acid-reactive substances (TBARS) and protein oxidation end-products compared to controls.
• M. stadtmanae presence was associated with lower 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the total sample and control group.
• In the sleep-disordered group, M. stadtmanae correlated with increased TBARS and Schiff bases.

Conclusions:

• The presence of intestinal Methanosphaera stadtmanae may be associated with increased oxidative stress, particularly in menopausal women experiencing sleep disturbances.
• Findings suggest a potential interplay between gut methanogens and endogenous oxidative processes, impacting sleep quality.
• Further research is warranted to elucidate the mechanisms underlying this interaction and its clinical implications.