Idiopathic Hyperprolactinemia: Clinical Presentation, Diagnosis, Management, and Clinical Outcome

Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder often presenting with menstrual irregularities, hyperandrogenism, and metabolic dysfunction. Hyperprolactinemia, characterized by elevated prolactin levels, may share overlapping features with PCOS and complicate diagnosis. When these two conditions coexist, they present unique clinical and management challenges. A 25-year-old woman with a history of PCOS presented with amenorrhea, progressive weight gain, and irregular menstrual cycles. Laboratory investigations revealed persistently elevated prolactin levels, while pituitary imaging ruled out structural abnormalities. The patient received lifestyle modification advice and dopamine agonist therapy, with continuous monitoring of hormonal, metabolic, and psychological parameters. This case highlights the diagnostic complexity of idiopathic hyperprolactinemia occurring in the context of PCOS, and emphasizes the importance of a multidisciplinary approach to management. Further clinical observations are needed to understand the neuropsychiatric effects of prolactin dysregulation.