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Cephalosporin-induced hemolytic anemia: a case study
Graça Almeida1, Ana Costa2, Eugénia Vasconcelos3
11Reference Laboratory of Immunohematology, Portuguese Institute of Blood and Transplantation, IPST, IP, Lisbon, Portugal.
Immunohematology
|January 9, 2026
Summary
This case report identifies cefuroxime and ceftriaxone as causes of drug-induced immune hemolytic anemia (DIIHA) in a child. Early diagnostic testing is crucial for identifying DIIHA, even with prior antibiotic tolerance.
Area of Science:
- Hematology
- Immunology
- Pediatrics
Background:
- Drug-induced immune hemolytic anemia (DIIHA) is a rare but severe condition, frequently observed in children receiving cephalosporins.
- A 10-year-old girl experienced severe hemolysis, hypovolemic shock, and renal dysfunction after cefuroxime and ceftriaxone administration.
- Previous tolerance to ceftriaxone did not prevent the adverse reaction in this patient.
