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UV–Vis Spectrometers01:14

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Ultrashort-Distance Internal Light Source-Integrated ECL-PEC Dual-Mode Molecular-Sensing Device for Highly Sensitive

Rong-Rong Zhao1, Yu-Ling Wang1, Bing Wang1

  • 1College of Chemistry and Chemical Engineering, Xinyang Key Laboratory of Functional Nanomaterials for Bioanalysis, Xinyang Normal University, Xinyang 464000, China.

Analytical Chemistry
|January 9, 2026
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Summary
This summary is machine-generated.

This study introduces a novel molecular-sensing device for enhanced photoelectrochemical (PEC) bioanalysis. The device achieves high sensitivity and accuracy by coupling an internal electrochemiluminescence (ECL) light source with dual-mode detection.

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Area of Science:

  • Analytical Chemistry
  • Biosensing Technology
  • Materials Science

Background:

  • Advancing photoelectrochemical (PEC) bioanalysis requires high sensitivity and accuracy, which are currently difficult to achieve simultaneously.
  • Existing methods face challenges in concurrently improving both sensitivity and accuracy in PEC bioanalysis.

Purpose of the Study:

  • To develop a novel molecular-sensing device for concurrent enhancement of sensitivity and accuracy in PEC bioanalysis.
  • To create a compact device integrating an internal electrochemiluminescence (ECL) light source with ECL-PEC dual-mode detection.

Main Methods:

  • Coupling an internal ECL light source (luminol-Au NPs) with a Bi2WO6 photoelectrode.
  • Utilizing an enzyme-assisted target recycling amplification strategy for signal amplification.
  • Implementing ECL-PEC dual-mode detection for cross-validation and accuracy improvement.

Main Results:

  • The internal ECL light source efficiently triggered Bi2WO6 photoactivity within an ultrashort distance (≤8.16 nm).
  • The PEC property was enhanced over 20 times, significantly improving sensitivity.
  • Simultaneous ECL and PEC signal output enabled cross-validation, enhancing accuracy.

Conclusions:

  • The developed device achieves highly sensitive and accurate detection of microRNA-21.
  • The novel design demonstrates successful application in human serum samples.
  • This work offers a new approach for improving sensitivity and accuracy in trace bioanalysis.