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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
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Metabolic Messengers: testosterone.

Franck Mauvais-Jarvis1,2, Shalender Bhasin3

  • 1Hormone Therapy Clinic, Medicine Service, Southeast Louisiana New Orleans VA Medical Center, New Orleans, LA, USA. fmauvais@tulane.edu.

Nature Metabolism
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PubMed
Summary
This summary is machine-generated.

Testosterone is a vital hormone for both sexes, acting directly and indirectly to regulate metabolism. Its discovery and synthesis revolutionized hormone replacement therapy and continue to be crucial for metabolic homeostasis.

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Area of Science:

  • Endocrinology
  • Metabolic Science
  • Hormone Biology

Background:

  • Testosterone, synthesized in the 1930s, is the first hormone used for replacement therapy.
  • It functions via androgen receptors (AR) and as a prohormone for oestrogen.
  • Testosterone metabolites like dihydrotestosterone also play significant roles.

Purpose of the Study:

  • To review the historical milestones in testosterone discovery and therapeutic uses.
  • To synthesize current knowledge on testosterone's role in metabolic regulation.
  • To highlight testosterone's importance in maintaining metabolic homeostasis.

Main Methods:

  • Historical review of testosterone's discovery and applications.
  • Synthesis of preclinical and human studies on testosterone's metabolic functions.
  • Analysis of signaling pathways including androgen and oestrogen receptors.

Main Results:

  • Testosterone impacts metabolism through direct and indirect pathways.
  • Metabolites like oestradiol and dihydrotestosterone are crucial mediators.
  • Genomic and non-genomic actions of testosterone and its metabolites are involved.

Conclusions:

  • Testosterone is essential for metabolic homeostasis in both males and females.
  • Understanding testosterone's multifaceted roles is critical for therapeutic applications.
  • Ongoing research continues to reveal the systemic metabolic importance of testosterone.