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Updated: Jan 13, 2026

Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings
Published on: August 19, 2021
A Rational Approach to Developing a Phage Biopreparation: Boosting Lytic Efficiency and Countering Resistance in
E R Zulkarneev1, N V Pimenov2, A S Tishchenko3
1Moscow State Academy of Veterinary Medicine and Biotechnology Named after K. I. Skryabin, Moscow, Russia. elzz@mail.ru.
None:
The antimicrobial activity of Escherichia phage Ec1-7 and Escherichia phage Ec2-7 was evaluated both separately and in a phage cocktail. The combination of phages significantly extended the spectrum of lytic activity and effectively inhibited the growth of bacteria, including strains with emerging resistance. The phage cocktail exhibited higher efficacy (3.6-4.8 lg(CFU/ml)) in comparison with monophages (1.3-2.8 lg(CFU/ml)) during a 6-h incubation period: it prevented secondary bacterial growth and reduced the likelihood of resistance development. Our findings corroborate the potential of phage cocktails in combating antibiotic-resistant strains.
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