Chrysin as a Multifunctional Therapeutic Flavonoid: Emerging Insights in Pathogenesis Management: A Narrative Review

Chrysin, a vital flavonoid found in fruits, vegetables, honey, and propolis, plays a significant role in the management of various pathogenesis. Its ability to reduce oxidative stress and mitigate inflammation is a reassuring factor in disease management. In addition, its role in various cancers has been demonstrated and it modulates cell signaling pathways, including inflammation, angiogenesis, apoptosis, autophagy, and the cell cycle. The literature was collected using search engines such as Google, Google Scholar, PubMed, and Scopus. Keywords included chrysin sources, antioxidant and anti-inflammatory activity, cardioprotective and hepatoprotective effects, as well as anti-diabetic, neuroprotective, anti-cancer, antimicrobial, and bone-protective roles. Research and review articles, along with relevant clinical trials published in English, were included. This narrative review summarizes the therapeutic potential of chrysin in the management of chronic diseases. Additionally, combination therapies of chrysin with other drugs/natural compounds provide synergistic benefits, leading to increased efficacy and lower toxicity. Despite its promising pharmacological activities, the clinical utility of chrysin remains limited due to its poor bioavailability, low solubility, limited permeability, and rapid metabolism. Overcoming these challenges will require the development of advanced formulations, mechanistic studies, and well-designed clinical trials to fully exploit chrysin's potential role in disease management.