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MXene-based functional nanodrugs towards anticancer strategy and augmented sonodynamic therapy
Xueyan Wang1, Jialu Li1, Ru Li1
1College of Chemistry and Chemical Engineering, Instrumental Analysis Center, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Qingdao University, 266071 Qingdao, China.
Biochimica Et Biophysica Acta. Reviews on Cancer
|January 10, 2026
Summary
MXene-based nanodrugs and sonodynamic therapy (SDT) show promise for cancer treatment. This review explores their combined use to enhance anticancer activity and discusses future innovations for clinical applications.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- MXene-based nanodrugs offer unique properties like conductivity and functionalizability.
- Sonodynamic therapy (SDT) provides noninvasive, deep-penetrating cancer treatment advantages.
Purpose of the Study:
- To review the synergistic effects of MXene nanodrugs and SDT for improved anticancer activity.
- To explore MXenes as sonosensitizers in SDT and theranostics.
Main Methods:
- Systematic review of MXene-based nanodrugs in single and combinatorial cancer therapy.
- Analysis of MXene-integrated multimodal SDT platforms for cancer treatment.
Main Results:
- MXene-based nanodrugs enhance SDT efficacy through various design strategies.
- Successful applications of MXene-harmonized SDT platforms in preclinical cancer models are discussed.
Conclusions:
- The combination of MXenes and SDT presents a promising strategy for advanced cancer therapy.
- Further theoretical and technical innovations are needed for successful clinical translation.
