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Effect of Vitamin D on Orthodontic Tooth Movement
Renu Renu1, Monica Chaurasia2, Dolma Ganz3
1Department of Dentistry, Government Medical College, Pali, Rajasthan, India.
Journal of Pharmacy & Bioallied Sciences
|January 12, 2026
Summary
Vitamin D supplementation significantly accelerates orthodontic tooth movement by improving bone density around teeth. This study found increased canine retraction rates in participants receiving Vitamin D injections compared to placebo, with no adverse effects.
Area of Science:
- Orthodontics
- Endocrinology
- Bone Biology
Background:
- Orthodontic tooth movement is a complex biological process influenced by bone remodeling.
- Vitamin D plays a crucial role in calcium homeostasis and bone health, potentially impacting orthodontic treatment outcomes.
Purpose of the Study:
- To investigate the effect of Vitamin D supplementation on the rate of orthodontic tooth movement.
- To determine if Vitamin D influences the bone remodeling process relevant to tooth movement.
Main Methods:
- A randomized controlled trial involving 30 participants (18-25 years) undergoing canine retraction post-premolar extraction.
- Group A received monthly 600,000 IU Vitamin D3 injections for 3 months; Group B received a placebo.
- Standardized spring force (150g) applied, with canine movement measured at 0, 4, 8, and 12 weeks. Serum Vitamin D levels were assessed at baseline and post-treatment.
Main Results:
- Statistically significant greater tooth movement in the Vitamin D group (Group A) compared to placebo (Group B) at 12 weeks (2.85 ± 0.32 mm vs. 1.97 ± 0.28 mm, P < 0.001).
- Serum 25(OH)D levels in Group A increased significantly post-intervention (52.4 ± 6.7 ng/mL).
- No adverse symptoms were reported by participants in either group.
Conclusions:
- Vitamin D supplementation enhances the rate of orthodontic tooth movement.
- The positive effect is likely mediated by improved bone quality and remodeling around the teeth.
- Vitamin D appears to be a safe adjunct in orthodontic treatment.
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