Related Experiment Video
Updated: Jan 13, 2026

Author Spotlight: Translational Applications of Stimulated SFEMG in Rodent Models
Published on: March 8, 2024
A Novel Anesthetic in Thomsen Myotonia Congenita With Rocuronium and Sugammadex: A Case Report
Tia K Shutes1, William F McCormick2, Robert M Harris2
1From the Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
Abstract:
This report describes the use of continuous rocuronium infusion for paralysis during 2 extensive spinal surgeries in a pediatric patient with Thomsen myotonia congenita. Although paralytics are typically avoided to allow motor-evoked potential monitoring, in this case, paralysis was required to reduce myotonic episodes and related complications. Rocuronium infusion with sugammadex reversal was used successfully, with only one presumed myotonic episode and no serious sequelae. This novel approach highlights the need for anesthesiologists to balance monitoring considerations with patient safety. Our report provides practical guidance to optimize outcomes in similar cases and expand the literature on myotonia management.
Related Concept Videos
Skeletal Muscle Relaxants: Therapeutic Uses
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Depolarizing Blockers: Pharmocokinetics
Depolarizing Blockers: Mechanism of Action
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
Local Anesthetics: Clinical Application as Spinal Anesthesia
Nondepolarizing (Competitive) Neuromuscular Blockers: Mechanism of Action
Competitive antagonists prevent acetylcholine from binding to its receptor, inhibiting membrane depolarization. Without conformational changes or intrinsic...

