Novel physiological analysis using oxygen saturation imaging endoscopy for colorectal polyps: a pilot study (with...

Area of Science:

• Gastroenterology
• Medical Imaging
• Oncology

Background:

• Oxygen saturation imaging endoscopy noninvasively maps real-time oxygen saturation (StO2).
• This technology allows for objective StO2 evaluation in colorectal polyps.

Purpose of the Study:

• To objectively evaluate StO2 in colorectal polyps (adenomas, hyperplastic polyps, sessile serrated lesions) using oxygen saturation imaging endoscopy.
• To correlate StO2 measurements with hypoxia-inducible factor 1-alpha (HIF1α) expression.

Main Methods:

• Examined 133 colorectal lesions (78 adenomas, 35 hyperplastic polyps, 20 sessile serrated lesions).
• Assessed lesion StO2 and StO2 difference from surrounding mucosa using oxygen saturation imaging.
• Performed immunohistochemistry for HIF1α expression.

Main Results:

• Mean StO2 was significantly lower in all lesion types compared to surrounding mucosa.
• Adenomas exhibited a significantly greater StO2 difference compared to hyperplastic polyps and sessile serrated lesions.
• HIF1α expression was significantly higher in adenomas than in hyperplastic polyps and sessile serrated lesions, with an inverse correlation between StO2 and HIF1α in adenomas.

Conclusions:

• Colorectal adenomas demonstrate significantly lower StO2, indicating greater hypoxia compared to other polyps.
• Oxygen saturation imaging endoscopy assessment of mucosal StO2 may aid in distinguishing aggressive colorectal neoplastic lesions.