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Related Experiment Video

Updated: Jan 15, 2026

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Photodynamic therapy and its evolving innovation.

Joshua Phipps1, Wenlu Fan1, Mansi Kapoor1

  • 1Department of Chemistry, University of North Texas, 76201, USA. Shengqian.ma@unt.edu.

Chemical Communications (Cambridge, England)
|January 14, 2026
PubMed
Summary
This summary is machine-generated.

Photodynamic therapy (PDT) uses light-activated photosensitizers to treat diseases, especially cancer. Recent advances leverage porous materials like MOFs and COFs for enhanced PDT applications and future potential.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Photochemistry

Background:

  • Light has been historically used for medical treatments.
  • Photodynamic therapy (PDT) utilizes photosensitizers activated by light to generate reactive oxygen species for therapeutic purposes.
  • PDT is widely applied in cancer treatment.

Purpose of the Study:

  • To review the historical development of photodynamic therapy (PDT).
  • To highlight innovative designs and advancements in PDT.
  • To emphasize the role of porous materials in recent PDT success and future outlook.

Main Methods:

  • Historical review of photodynamic therapy (PDT) evolution.
  • Analysis of innovative PDT designs and applications.
  • Examination of porous materials (MOFs, COFs, porous polymers) in PDT.

Main Results:

  • Porous materials, including metal-organic frameworks (MOFs), covalent-organic frameworks (COFs), and nanoscale porous polymers, have significantly advanced PDT.
  • These materials enhance PDT efficacy and offer new therapeutic possibilities.
  • The review provides a comprehensive overview of PDT's innovative trajectory.

Conclusions:

  • Porous materials are instrumental in the recent success and future potential of photodynamic therapy (PDT).
  • PDT continues to evolve with innovative material integration.
  • This review offers a foundational understanding of PDT's past, present, and future.