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Updated: Jan 15, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
Forces behind N- and C-capping of peptidic helices
Tianxiong Mi1, Lorenz Mattes2, Thitima Pewklang1
1Department of Chemistry, Texas A & M University, Box 30012, College Station, Texas 77842, USA. burgess@tamu.edu.
None:
Helical peptides are primarily stabilized by intramolecular hydrogen bonds. Particular conformational arrangements, capping motifs, help precisely terminate helices by compensating for disruption of helical H-bonding patterns. This contribution explores if: (i) N-and C-caps are essentially the same; and, (ii) how differences impact their thermodynamic helix stabilities and folding kinetics.
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