Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

937
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
937
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

540
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
540
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

478
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
478
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

838
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
838
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.4K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Malignant teratoid medulloepithelioma with retinal invasion masquerading as vasoproliferative retinal tumor in an adult.

American journal of ophthalmology case reports·2026
Same author

Optical Coherence Tomography Features of Retinal Leukemic Infiltrates and Their Association With Visual Prognosis.

Journal of vitreoretinal diseases·2026
Same author

Evidence and Consensus Based Guidelines for Imaging in Tubercular Choroiditis. Multimodal imaging in Uveitis (MUV) Taskforce: Report 17.

Ophthalmology. Retina·2026
Same author

Accuracy of Retinal Pigment Epithelium (RPE) undulations (Oscillatory sign) as an optical coherence tomography biomarker of acute RPE tears.

International journal of retina and vitreous·2026
Same author

Late Diagnostic Revision to Tubercular Choroiditis in Patients with Recurrent APMPPE: A Retrospective Study in 28 Cases.

Ocular immunology and inflammation·2026
Same author

Effect of Anti-Tubercular Therapy Duration (6 Months versus ≥9-Months) on Treatment Outcomes in Serpiginous-Like Choroiditis: A Multicenter Retrospective Observational Study.

Ocular immunology and inflammation·2026
Same journal

Advancing Retinal Vessel Analysis: Reproducibility of Myogenic Constriction and Assessment of Regulatory Capacity.

Translational vision science & technology·2026
Same journal

Optical Quality and Centration Stability of a Novel Capsule Reconstructor for Intraocular Lens Fixation: Laboratory Evaluation of the fixOflex Device.

Translational vision science & technology·2026
Same journal

The Role of Nrf2 in SIRT1-Mediated RGC Neuroprotection in Traumatic Optic Neuropathy.

Translational vision science & technology·2026
Same journal

Explicit Inclusion of Diabetes Mellitus Without Retinopathy Within Diabetic Retinopathy Prediction.

Translational vision science & technology·2026
Same journal

Preclinical Safety and Feasibility Study of Line-Field Confocal Optical Coherence Tomography for Ophthalmology Applications.

Translational vision science & technology·2026
Same journal

Pathogenicity Analysis of Two Novel CRB1 Mutations in Three Chinese Inherited Retinal Dystrophy Families and a Literature Review.

Translational vision science & technology·2026
See all related articles

Related Experiment Video

Updated: Jan 17, 2026

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

3.1K

Persistent Inflammation After Anti-Tubercular Therapy in Tubercular Serpiginous-Like Choroiditis: A Multivariate and

Natasha Kesav1,2, Shabtab Nasir1, Mohammed Hasnat Ali3

  • 1Saroja A Rao Center for Uveitis, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India.

Translational Vision Science & Technology
|January 14, 2026
PubMed
Summary
This summary is machine-generated.

Persistent inflammation in tubercular serpiginous-like choroiditis (TB-SLC) after antitubercular therapy (ATT) is linked to insufficient initial immunosuppression. Ongoing inflammation during ATT increases the risk of persistent inflammation post-treatment.

More Related Videos

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

19.2K
A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
03:47

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

607

Related Experiment Videos

Last Updated: Jan 17, 2026

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

3.1K
Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

19.2K
A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
03:47

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

607

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Immunology

Background:

  • Tubercular serpiginous-like choroiditis (TB-SLC) requires antitubercular therapy (ATT), but treatment outcomes can vary.
  • Persistent inflammation post-ATT poses a challenge in managing TB-SLC.
  • Understanding risk factors for persistent inflammation is crucial for optimizing treatment strategies.

Purpose of the Study:

  • To investigate the risk factors associated with persistent inflammation in patients with TB-SLC following completion of ATT.
  • To identify clinical variables that predict treatment failure or recurrence.

Main Methods:

  • Retrospective review of TB-SLC patients who completed at least 6 months of ATT.
  • Analysis of persistent inflammation at ATT completion as the primary outcome.
  • Multivariate logistic regression and categorical network analysis to identify risk factors and their interrelationships.
  • Quantification of anti-inflammatory therapy using total immunosuppressive load (TIL).

Main Results:

  • Out of 65 patients, 18.5% exhibited ongoing inflammation after ATT.
  • Lower mean TIL at month 1 of ATT (aOR, 0.64) and persistent inflammation at month 3 (aOR, 13.44) were significant risk factors for post-ATT inflammation.
  • Network analysis indicated associations between low initial TIL, 3-month persistence, paradoxical worsening, and shorter ATT duration.

Conclusions:

  • Initial immunosuppression levels are critical in preventing persistent inflammation post-ATT for TB-SLC.
  • Ongoing inflammation during ATT treatment is a significant predictor of persistent inflammation after therapy completion.
  • Factors like paradoxical worsening and ATT duration may influence these outcomes.