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Atomic Force Microscopy

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Updated: Jan 17, 2026

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

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Non-proximate, Hand-Held Probe with Positional Feedback for Real-Time Analysis of Three-Dimensional Object Surfaces.

G Asher Newsome¹

¹Smithsonian Museum Conservation Institute, Suitland, Maryland 20746, United States.

Journal of the American Society for Mass Spectrometry

|January 15, 2026

Summary

This summary is machine-generated.

A novel flexible gooseneck transfer tube enhances non-proximate desorption photoionization (NPDPI) analysis. This system minimizes analyte loss and enables real-time analysis of complex surfaces without direct line of sight.

Keywords:

NPDPI ambient sampling passivation photoionization thermal desorption

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Area of Science:

Analytical Chemistry
Spectroscopy
Materials Science

Background:

Non-proximate mass spectrometry techniques often suffer from analyte loss and signal carryover.
Existing methods utilize unheated plastic tubing, leading to inefficiencies in sampling organic analytes from distant surfaces.

Purpose of the Study:

To develop a flexible and efficient transfer system for non-proximate desorption photoionization (NPDPI).
To enable real-time analysis of analytes from complex and inaccessible surface geometries.

Main Methods:

A novel gooseneck transfer tubing design was implemented, offering flexibility and reduced analyte adsorption.
An integrated desorption probe with a heated gas jet and contact sensors was developed for user-friendly operation.
Neutrally desorbed analytes were transferred up to 4 meters to a doped photoionization source.

Main Results:

The new gooseneck tubing significantly reduced organic molecule loss compared to traditional plastic tubing.
Real-time analysis was successfully demonstrated on surfaces with narrow dimensions and blind concave geometries.
Both volatile and involatile analytes were detected from various commonplace objects.

Conclusions:

The flexible gooseneck NPDPI system overcomes limitations of previous non-proximate sampling techniques.
This advancement allows for efficient and clean analysis of challenging sample surfaces.
The technology holds promise for expanded applications in trace analyte detection and surface characterization.