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The Hype and the Hope: Where Do We Stand with Prostate-specific Membrane Antigen-targeted Fluorescence-guided

Vera A Ottens1, Giuseppe Chiarelli2, Roberto Contieri3

  • 1Netherlands Cancer Institute, Antoni van Leeuwenhoek Ziekenhuis, Amsterdam, The Netherlands; Interventional Molecular Imaging Laboratory, Leiden University Medical Centre, Leiden, The Netherlands.

European Urology
|January 15, 2026
PubMed

Insights

Prostate-specific membrane antigen-targeted fluorescence-guided surgery shows early promise. Further technical improvements and clinical evidence are needed to maximize its oncological benefits.

Area of Science:

  • Oncology
  • Surgical Innovation
  • Medical Imaging

Background:

  • Prostate-specific membrane antigen (PSMA) is a promising target for cancer diagnostics and therapeutics.
  • Fluorescence-guided surgery (FGS) offers real-time visualization to improve surgical precision.
  • Early research indicates potential for PSMA-targeted FGS in various oncological procedures.

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