Two-Stage Revision Arthroplasty for Salmonella enteritidis Periprosthetic Hip Infection

Periprosthetic joint infections (PJIs) are severe complications following joint arthroplasty, commonly caused by Gram-positive bacteria, such as Staphylococcus aureus. Infections due to Gram-negative organisms like Salmonella enteritidis are exceedingly rare. In this study, we report a case of a 68-year-old male who developed a late-onset PJI caused by Salmonella enteritidis 10 years after primary total hip arthroplasty (THA). A two-stage revision arthroplasty with an interim antibiotic spacer was performed, followed by 6 weeks of intravenous antibiotic therapy. Three months postoperatively, the patient demonstrated full recovery with normal function. This case highlights the necessity of considering uncommon pathogens like Salmonella enteritidis in PJIs, even in patients without identifiable predisposing factors, and underscores the effectiveness of combined surgical and targeted antimicrobial therapy.