Palladium(II)-Catalyzed Direct C7-Acyloxylation of Indoles
Xianyu Zhang1, Jingwen Wang1, Shengrong Chen1
1State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350116, China.
Abstract:
We report a palladium-catalyzed C-H acyloxylation of indoles that achieves excellent regioselectivity at the C7 position. The synergistic combination of a methylsulfonyl directing group and a pyridone-based ligand was crucial to overriding the inherent preference for functionalization at the C3 position. The reaction features a broad substrate scope and good functional group tolerance and provides direct access to valuable 7-acyloxylated indole derivatives.
More Related Videos
Related Concept Videos
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Preparation of Diols and Pinacol Rearrangement
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.
Vicinal Diols via Reductive Coupling of Aldehydes or Ketones: Pinacol Coupling Overview
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide


