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Published on: July 13, 2014
Comparative Characteristics of Morphometric Changes in the Brain Tissue Caused by Prenatal Alcohol Exposure and
S N Shumilova1,2, A V Solonsky3,4, A V Potapov4
1Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. sofashumilova97@gmail.com.
Abstract:
According to current knowledge, hypoxia is a key mechanism mediating the detrimental effects of prenatal alcohol exposure on the nervous tissue. However, comparative analysis of these interrelated conditions has only been partially addressed. We conducted a morphometric analysis of fetal brain tissue affected by chronic alcohol exposure and hypoxia. A decrease in the specific area of neuroblasts, glioblasts, and microvascular elements was found. Hypoxia promoted enlargement of neuroblasts and their differentiation into immature neurons, whereas alcohol exposure led only to a decrease in their number. In the brain subjected to hypoxia, glioblasts were characterized by size variability with a general trend toward reduction, while alcohol had no significant effect on their size. Both experimental groups showed a decline in vascular density.
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