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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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Related Experiment Video

Updated: Jan 19, 2026

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
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An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

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Carbon-based quantum dots enhance platelets aggregation through migrasomes biogenesis.

Ang Li1,2,3, Leiliang Zhang4,5

  • 1Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.

Journal of Nanobiotechnology
|January 17, 2026
PubMed
Summary
This summary is machine-generated.

Sub-10 nm quantum dots, including carbon quantum dots (CQD), graphene quantum dots (GQD), and graphitic oxide quantum dots (GOQDs), significantly enhance migrasome formation and platelet function. These nanoparticles also protect mitochondria via mitocytosis.

Keywords:
CQDGOQDsGQDMigrasomesPlatelet aggregation

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Cell Biology

Background:

  • Previous research focused on larger nanoparticles (>20 nm) for migrasome formation.
  • The biological impact of sub-10 nm nanomaterials on cellular processes remains underexplored.

Purpose of the Study:

  • To investigate the effects of sub-10 nm carbon-based quantum dots on migrasome formation.
  • To explore the influence of these nanoparticles on mitochondrial integrity and platelet function.

Main Methods:

  • Application of sub-10 nm carbon quantum dots (CQD), graphene quantum dots (GQD), and graphitic oxide quantum dots (GOQDs).
  • Analysis of migrasome formation, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), cholesterol, and GTP-RhoA levels.
  • Assessment of mitochondrial integrity and platelet aggregation.

Main Results:

  • Sub-10 nm CQDs, GQDs, and GOQDs significantly induce migrasome formation.
  • These nanoparticles upregulate PI(4,5)P2, cholesterol, and GTP-RhoA, promoting migrasome formation.
  • Nanoparticles demonstrated mitochondrial protection via mitocytosis and enhanced platelet aggregation.

Conclusions:

  • Sub-10 nm graphene quantum dots are potent inducers of migrasome formation.
  • These nanomaterials offer protective effects on mitochondria and enhance platelet function.
  • This study pioneers the link between nanoscale graphene materials and migrasome dynamics.