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Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
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Drug-Induced Fuchs Syndrome With Isolated Oral Involvement: A Rare Case Report.

Salina Paudel1, Manoj Kumar Bhatt2, Shiv Kumar Chaudhary3

  • 1Department of Internal Medicine, Tuberculosis Treatment Center, Pokhara, Gandaki, Nepal.

Case Reports in Dermatological Medicine
|January 19, 2026
PubMed
Summary
This summary is machine-generated.

Stevens-Johnson syndrome (SJS) can present as isolated oral lesions, known as Fuchs syndrome, often triggered by medications like amoxicillin. Early recognition and supportive care are crucial for recovery from this rare condition.

Keywords:
Fuchs syndromeStevens–Johnson syndromeamoxicillindelayed hypersensitivityoral mucositis

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Area of Science:

  • Dermatology
  • Pediatrics
  • Infectious Diseases

Background:

  • Stevens-Johnson syndrome (SJS) is a severe mucocutaneous disorder, typically drug-induced, presenting with epidermal necrosis and mucosal lesions.
  • A rare variant, Fuchs syndrome, involves isolated mucosal lesions without skin involvement, often mimicking other oral pathologies.
  • Mycoplasma pneumoniae infection and certain medications are common triggers for Fuchs syndrome, posing diagnostic challenges.

Purpose of the Study:

  • To report a case of Fuchs syndrome presenting as isolated oral lesions in a pediatric patient.
  • To highlight the diagnostic challenges and importance of early recognition in atypical SJS presentations.
  • To emphasize the role of prompt, supportive management in achieving favorable outcomes.

Main Methods:

  • Case report of a 6-year-old boy with isolated oral lesions after amoxicillin exposure.
  • Clinical assessment focusing on mucosal lesions and patient history.
  • Supportive management and monitoring for recovery.

Main Results:

  • The patient developed isolated oral mucosal lesions consistent with Fuchs syndrome following amoxicillin therapy.
  • Prompt diagnosis and supportive care led to complete resolution of symptoms.
  • No recurrence or significant complications were observed.

Conclusions:

  • Atypical presentations of SJS, such as Fuchs syndrome, require vigilant clinical suspicion.
  • Amoxicillin can be a trigger for isolated mucosal SJS (Fuchs syndrome) in children.
  • Early identification and intervention are key to successful management and preventing severe outcomes.