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A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
Data resource profile: the Scottish Combined Medicines Dataset (SCoMeD).
Tanja Mueller1,2, Lynne Jarvis1, Victoria Stark1
1Public Health Scotland, Gyle Square, 1 South Gyle Crescent, Edinburgh EH12 9EB, United Kingdom.
The Scottish Combined Medicines Dataset (SCoMeD) unifies disparate prescribing records into a single longitudinal view. This enables comprehensive analysis of patient medicine use across all National Health Services (NHS) Scotland care settings.
Area of Science:
- Health Informatics
- Pharmaceutical Sciences
- Public Health
Background:
- Electronic prescribing data in Scotland existed in separate datasets (primary, secondary care).
- A unified view was needed for longitudinal patient medicine use analysis across NHS Scotland.
- Existing data silos limited comprehensive research and patient care insights.
Purpose of the Study:
- To create a unified, longitudinal dataset of all prescribing information in Scotland.
- To facilitate research by integrating data from primary, secondary, and homecare settings.
- To enable linkage with other health datasets for broader analytical capabilities.
Main Methods:
- Developed the Scottish Combined Medicines Dataset (SCoMeD) using data virtualization.
- Integrated data from Prescribing Information System (PIS), Hospital Electronic Prescribing and Medicines Administration (HEPMA), and Homecare Medicines (HCM).
- Utilized unique patient identifiers (Community Health Index number) for cohort creation and data linkage.
Main Results:
- SCoMeD provides a consolidated view of patient demographics and medication details (what, when, strength, dose).
- Data availability spans from January 2010 (PIS), January 2019 (HCM), and July 2022 (HEPMA).
- The dataset enables patient cohort identification and linkage to hospital admissions and death records.
Conclusions:
- SCoMeD supports diverse study types, including cross-sectional, drug utilization, and longitudinal research.
- The integrated dataset facilitates health policy and health economics evaluations.
- Data access requires approval via the electronic Data Research and Innovation Service.
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