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Updated: Jan 20, 2026
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Collagenous gastritis: A rare entity with common clinical features
Paruvathavarthini Thambiraj1, Kalaivanan Balasubramanian, Bheemanathi Hanuman Srinivas
1Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Indian Journal of Pathology & Microbiology
|January 19, 2026
Summary
Collagenous gastritis, a rare condition, involves subepithelial collagen thickening. This case report details its diagnosis in a young adult female presenting with gastrointestinal symptoms.
Area of Science:
- Gastroenterology
- Pathology
Background:
- Collagenous gastritis (CG) is a rare gastrointestinal disorder.
- It is defined by excessive subepithelial collagen deposition (>10 μm) in the stomach.
- CG can present with non-specific upper gastrointestinal symptoms.
Purpose of the Study:
- To report a case of collagenous gastritis in a young adult female.
- To highlight the diagnostic features of CG on endoscopy and histology.
Main Methods:
- A young adult female presented with upper gastrointestinal symptoms.
- Upper gastrointestinal endoscopy was performed, revealing atrophic gastric mucosa.
- A biopsy was obtained for histopathological examination.
Main Results:
- Histopathology confirmed increased collagen deposition exclusively in the subepithelial layer.
- Masson's trichrome stain effectively highlighted the collagenous thickening.
- The findings were consistent with the diagnostic criteria for collagenous gastritis.
Conclusions:
- Collagenous gastritis is a rare condition that can affect young adults.
- Endoscopic findings of atrophic mucosa may warrant further investigation.
- Histopathological examination with specific stains is crucial for diagnosing collagenous gastritis.
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