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Updated: Jan 20, 2026
Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron
Published on: August 12, 2019
Rhodium-catalyzed Z-alkenylation of gem-difluoropropenes: access to fluorinated (1Z,4Z)-dienes
Jiang-Min Yan1, Kai-Xian Ma1, Rui-Hong Chen1
1School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. liuschop@swu.edu.cn.
Abstract:
An effective method for constructing thermodynamically unstable 1Z,4Z-dienes via Rh-catalysed cross-coupling of allylic gem-difluorides with tertiary Z-allylic alcohols has been developed. The fluoride elimination of the gem-difluoride propenes and β-Z-alkenyl elimination of the tertiary Z-allylic alcohols have been combined smoothly. This transformation furnishes a series of fluorinated (1Z,4Z)-dienes in moderate-to-high yields under mild conditions, exhibiting broad substrate scope, excellent functional group tolerance, and excellent chemo- and regioselectivity.
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