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Bicuspid aortic valve phenotype relationship with aortic root morphology and elasticity
Riza Kaya1, Onur Baydar2, Umit Yasar Sinan3
1Department of Cardiology, Istanbul University Institute of Cardiology, Haseki, Aksaray, 34350, Istanbul, Turkey. drrizakaya@gmail.com.
Journal of Ultrasound
|January 20, 2026
Summary
Bicuspid aortic valve (BAV) subtype did not correlate with aortic root shape. However, non-raphe BAV patients exhibited reduced aortic distensibility, indicating a higher risk for future aortic complications.
Area of Science:
- Cardiovascular Research
- Medical Imaging
- Biomechanical Engineering
Background:
- Bicuspid aortic valve (BAV) is a common congenital heart defect associated with aortic root abnormalities.
- Understanding the relationship between BAV subtypes, aortic root morphology, and mechanical properties is crucial for predicting disease progression.
Purpose of the Study:
- To investigate the association between different bicuspid aortic valve (BAV) subtypes and aortic root shape.
- To evaluate the impact of BAV on aortic mechanical properties, including strain, distensibility, and stiffness.
Main Methods:
- Retrospective analysis of 88 patients with BAV using transesophageal echocardiography (TEE).
- Assessment of aortic dimensions and shapes in all patients.
- Measurement of aortic mechanical properties (strain, distensibility, stiffness) in 37 patients.
Main Results:
- Aortic shape did not show a significant association with BAV subtypes (Type 1, 2, 3).
- Patients with raphe in Type 1 BAV demonstrated superior aortic mechanics compared to those without raphe.
- Non-raphe BAV patients exhibited significantly lower aortic distensibility and higher stiffness.
Conclusions:
- BAV subtype is not predictive of aortic root shape.
- Reduced aortic distensibility in non-raphe BAV patients suggests an increased susceptibility to aortic complications.
- Further longitudinal studies are warranted to confirm these findings and guide clinical management.
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