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Area of Science:

  • Ophthalmology
  • Optometry
  • Clinical Research

Background:

  • Investigating the real-world efficacy of Peripheral Defocus spectacle lenses (PDL) for myopia control.
  • Assessing if PDL effectiveness in clinical trials translates to standard practice.

Purpose of the Study:

  • To evaluate the myopia control efficacy of PDL compared to Single Vision (SV) lenses in a clinical environment.
  • To analyze axial elongation and spherical equivalent changes in myopic patients treated with PDL versus SV lenses.

Main Methods:

  • Retrospective analysis of clinical records from University Eye Hospital Basel (2019-2024).
  • Inclusion criteria: myopia diagnosis, at least three axial eye length measurements, and exclusive use of PDL or SV lenses.
  • Comparison of axial elongation and spherical equivalent using independent t-tests (p < 0.05 significance).

Main Results:

  • PDL significantly reduced axial elongation compared to SV lenses at 6, 12, and 18 months in both eyes.
  • At 18 months, significant differences in axial elongation were observed (p < 0.001 for both eyes).
  • No consistent trend in spherical equivalent was noted, with a significant difference only in the right eye at 18 months (p = 0.044).

Conclusions:

  • PDL lenses demonstrate significant efficacy in reducing myopic axial elongation in a real-world clinical setting.
  • Findings support previous controlled trial results, validating PDL as an effective tool for myopia management.
  • The study supports the clinical adoption of PDL for managing myopia progression.