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The Integrated Stress Response in Cancer: Paradox and Therapeutic Promise

Chenliang Zhang1, Ting Zhang2, Qiulin Tang3

  • 1Division of Abdominal Tumor, Department of Medical Oncology, Cancer Center, Laboratory of Abdominal Tumor Immunology and Microenvironment, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Comprehensive Physiology
|January 22, 2026
PubMed
Summary

The integrated stress response (ISR) pathway helps cancer cells survive but can also trigger cell death. Targeting the ISR offers therapeutic potential, but its dual role requires careful consideration for effective cancer treatment strategies.

Keywords:
ATF4apoptosisdrug resistanceeIF2αintegrated stress responsetumor immunotherapytumor therapy

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