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Extensive Lymphadenopathy in an HIV-Negative Patient With Multidrug-Resistant Tuberculosis
Tomoyuki Araya1, Toshiyuki Kita1, Kazuhiko Iwasaki1
1Department of Respiratory Medicine NHO Kanazawa Medical Center Kanazawa Ishikawa Japan.
Respirology Case Reports
|January 22, 2026
Summary
Tuberculous lymphadenitis can be severe in HIV-negative individuals with multidrug-resistant tuberculosis. This case shows extensive lymph node involvement and systemic symptoms are possible without HIV infection.
Area of Science:
- Infectious Diseases
- Immunology
- Microbiology
Background:
- Tuberculous lymphadenitis (TBL) is often more severe in individuals with HIV infection.
- Extrapulmonary tuberculosis (TB) can present with diverse clinical manifestations.
Purpose of the Study:
- To highlight a case of severe, extensive tuberculous lymphadenitis in an HIV-negative patient.
- To emphasize that significant lymph node involvement can occur in HIV-negative individuals with multidrug-resistant TB.
Main Methods:
- Case report presentation.
- Clinical and microbiological evaluation of a patient with multidrug-resistant tuberculosis.
Main Results:
- The patient, who was HIV-negative, developed severe and extensive lymphadenitis affecting multiple extrapulmonary sites.
- The presentation included pronounced systemic symptoms despite the absence of HIV infection.
Conclusions:
- Severe tuberculous lymphadenitis is not exclusive to HIV-infected patients.
- Multidrug-resistant tuberculosis can cause extensive lymph node disease and systemic symptoms in HIV-negative individuals.
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