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Updated: Jan 24, 2026
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Elevated Anxiety Levels in Central Serous Chorioretinopathy: Evidence from a Prospective Case-Control Study
Saloni Joshi1, Manavi D Sindal2, Maithili Umate3
1Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Pondicherry, India.
Summary
Patients with Central Serous Chorioretinopathy (CSCR) experience significantly higher rates of anxiety compared to healthy individuals. This suggests anxiety may contribute to CSCR development, highlighting the need for anxiety management in patient care.
Area of Science:
- Ophthalmology
- Psychiatry
- Endocrinology
Background:
- Central Serous Chorioretinopathy (CSCR) is an idiopathic condition affecting the macula.
- The role of psychological factors, particularly anxiety, in CSCR pathogenesis remains under investigation.
Purpose of the Study:
- To prospectively compare the prevalence and severity of anxiety disorders in patients with CSCR versus age- and gender-matched healthy controls.
Main Methods:
- A prospective, cross-sectional, case-control study involving 200 participants (100 CSCR patients, 100 controls) aged 18-55.
- Anxiety was assessed using the Hamilton Anxiety Rating Scale (HAM-A).
- Statistical analysis employed Chi-square/Fisher's exact tests.
Main Results:
- CSCR patients exhibited significantly higher rates of anxiety (mild, moderate, severe) compared to controls.
- The odds of having anxiety were approximately five times greater in the CSCR group (OR 5.71, p<0.0001).
- A majority of CSCR patients (82%) reported moderate to severe anxiety.
Conclusions:
- A strong association exists between anxiety and CSCR.
- Anxiety may influence the hormonal milieu, potentially increasing endogenous steroid secretion linked to CSCR.
- Managing anxiety and promoting lifestyle changes may be beneficial for CSCR patients.
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