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Factors Associated With Hormone Replacement Therapy Use: A Systematic Review and Meta-Analysis.

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PubMed
Summary
This summary is machine-generated.

Hormone replacement therapy (HRT) uptake varies significantly by ethnicity and health conditions. Black women showed lower HRT use compared to White women, while conditions like osteoporosis and depression were linked to higher uptake.

Keywords:
menopause: HRT regimensmeta‐analysissystematic reviews

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Area of Science:

  • Reproductive Health
  • Health Disparities
  • Evidence Synthesis

Background:

  • Hormone replacement therapy (HRT) is used to manage menopausal symptoms.
  • Factors influencing HRT uptake are not fully understood, particularly across diverse populations.

Purpose of the Study:

  • To systematically review and meta-analyze factors associated with HRT uptake in women aged 40-60.
  • To identify demographic, behavioral, and health-related predictors of HRT initiation.

Main Methods:

  • A comprehensive systematic review and meta-analysis of cohort, case-control, and cross-sectional studies.
  • Searched major databases (Medline, Embase, CINAHL, Cochrane) for relevant literature.
  • Included studies reporting on HRT uptake ('ever' vs. 'never' users) and associated factors.

Main Results:

  • 53 studies were included in the meta-analysis.
  • HRT uptake was 53% lower in Black women compared to White women.
  • Conditions such as diabetes, obesity, stroke, and venous thromboembolism were associated with lower HRT uptake, while osteoporosis and depression were linked to higher uptake.

Conclusions:

  • Significant differences in HRT uptake exist based on ethnicity and health characteristics.
  • Findings highlight potential inequities in HRT access and utilization.
  • Results can inform healthcare professionals and policymakers to improve HRT equity.