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Updated: Jan 24, 2026

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Intrahepatic Cholangiocarcinoma With Rare Metastasis Locations in a Younger Patient: A Case Report
Inês P Carvalho1, Adalmira Gomes1, Bárbara Pena2
1Internal Medicine, Centro Hospitalar Barreiro-Montijo, Barreiro, PRT.
Abstract:
Intrahepatic cholangiocarcinoma is a highly aggressive tumor, usually diagnosed in late middle age and often at an advanced stage. In this clinical case, we report the case of a 41-year-old woman presenting with diplopia, blurred vision, and headache for three days. Imaging investigations showed metastases in the liver, bone, lung, clivus, and rare locations for this type of cancer, such as the spleen and a soft tissue lesion with pre-protuberance expression. The biopsy of the liver lesions confirmed intrahepatic cholangiocarcinoma as the primary tumor. Awareness should be raised regarding the possible atypical symptoms of this cancer and the potential increase in incidence among younger age groups, which may be associated with worse outcomes.
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