Power Duo against Sensitivity: Ozone and Toothpaste Synergy - A Randomized Controlled Trial

Dentinal hypersensitivity (DH) is a frequent condition producing sharp, transient pain in response to external stimuli. Conventional desensitizing agents often provide only partial or short-term relief. This study evaluated the effectiveness of combining ozone therapy with desensitizing toothpaste compared with toothpaste alone in DH management.

A randomized controlled trial was conducted on 80 patients aged 18-65 years with moderate-to-severe DH at the Department of Oral Medicine and Radiology, Kalinga Institute of Dental Sciences, Bhubaneswar. Patients were allocated into two groups: the test group ( n = 40) received ozone therapy (ozonated olive oil and ozone gas) plus desensitizing toothpaste, and the control group ( n = 40) received 5% potassium nitrate toothpaste. Sensitivity was assessed at baseline and follow-up intervals (1 week, 2 weeks, 1 month, 3 months, and 6 months) using the Visual Analog Scale (VAS), Air Blast Sensitivity Test, and Sensitivity Clinical Assessment Scale (SCASS). Scanning electron microscopy was performed to assess dentinal tubule occlusion.

Both the groups showed significant sensitivity reduction. The test group achieved greater mean decreases in VAS (5.05 ± 1.11) and SCASS (5.23 ± 1.10) compared with the control group (VAS: 2.35 ± 1.03 and SCASS: 2.28 ± 0.88). Improvements in the test group were sustained for 6 months, whereas control results plateaued. No adverse effects were reported.

Ozone therapy with desensitizing toothpaste offers enhanced, long-lasting relief of dentinal hypersensitivity. Its antimicrobial, anti-inflammatory, and remineralizing actions support dentinal repair and patient comfort, representing a safe and effective adjunct to standard care.