Meta-Analysis of Treatment Methods for Poststroke Cognitive Impairment: A Network Analysis of Various Interventions

Poststroke cognitive impairment (PSCI) is a common neurological consequence of stroke that significantly impacts patients' quality of life and functional recovery. This meta-analysis aimed to evaluate and compare the efficacy of various treatment modalities for PSCI.

We conducted a systematic search of multiple databases and identified eligible randomized controlled trials (RCTs) investigating treatments for PSCI. Eleven RCTs with 904 participants evaluating seven different interventions were included in the network meta-analysis. The treatments included transcranial direct current stimulation (tDCS), acupuncture, Baduanjin exercise, transcranial ultrasound stimulation (TUS), moderate-intensity aerobic exercise, modified Suanzaoren decoction, and cognitive training alone (control).

Network meta-analysis showed that all interventions demonstrated some degree of efficacy compared to cognitive training alone, with Baduanjin exercise and tDCS ranking highest for improving cognitive function. Publication bias assessment showed no significant bias.

This comprehensive analysis suggests that non-pharmacological interventions, particularly neuromodulation techniques and traditional Chinese exercise, may offer promising approaches for PSCI treatment. These findings provide evidence-based guidance for clinical decision-making, though more large-scale, high-quality RCTs are needed to strengthen these conclusions.