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Risk of Measles Vaccine Associated Febrile Seizures among Children 6-59 Months Old in a Federally Qualified Health

Kate Kurlandsky1, Kristin Breslin1, Amy Stein1

  • 1Denver Health and Hospital Authority, Denver, CO.

The Journal of Pediatrics
|January 25, 2026
PubMed

Insights

Measles vaccination is rarely associated with febrile seizures in young children. This study found no cases of epilepsy developing after a measles vaccine, indicating a low risk for this serious neurological condition.

Area of Science:

  • Pediatric Medicine
  • Vaccinology
  • Epidemiology

Background:

  • Febrile seizures are common in young children.
  • Measles vaccination is a critical public health intervention.
  • Understanding vaccine safety is crucial for public trust.

Purpose of the Study:

  • To investigate the incidence of febrile seizures following measles vaccination.
  • To assess the long-term risk of epilepsy after measles vaccination.

Main Methods:

  • A 15-year retrospective cohort study.
  • Included 53,830 children aged 6-59 months.
  • Analyzed data from a Federally Qualified Health System.

Main Results:

  • Identified 10 cases of febrile seizures 7-14 days post-measles vaccination.
  • Incidence rate was 2.05 per 100,000 person-days.
  • All seizure cases had concurrent illnesses and received co-administered vaccines; no epilepsy developed.

Conclusions:

  • Febrile seizures following measles vaccination are rare.
  • No evidence suggests a link between measles vaccination and epilepsy.
  • The safety profile of measles vaccination remains favorable.

Keywords:
children 6-59 monthsfebrile seizurefederally qualified health systemmeasles vaccine

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