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Updated: Jan 27, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
Biomarkers in Irritable Bowel Syndrome: Rationale and Practical Use
1Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
None:
Irritable bowel syndrome (IBS) is currently diagnosed based on symptoms and limited diagnostic testing, highlighting the need for noninvasive biomarkers and personalized therapies. Emerging blood-based biomarkers such as cytolethal distending toxin B and antivinculin antibodies, DNA methylation profiles, and intestinal permeability measures, along with stool-based microbiome and metabolite markers, show promise in distinguishing IBS, and its bowel habit subtypes, from other gastrointestinal disorders with overlapping symptoms. Additionally, stool-based biomarkers and breath tests may also predict response to interventions, like the low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols diet, and rifaximin, supporting more personalized treatment strategies.
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