Related Experiment Video

Updated: Jan 27, 2026

A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

487

The Mediating Role of Immune Cells in the Genetically Predicted Relationship between Gut Microbiota and Puerperal

Yihui Chai1, Chunsong Gu2, Zhiliang Fan1

  • 1School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.

Endocrine, Metabolic & Immune Disorders Drug Targets
|January 26, 2026
PubMed
Abstract

Insights

Certain gut bacteria are causally linked to puerperal sepsis (PS). Immune cells, specifically IgD-CD27- B cells and CD62L- monocytes, partially mediate this risk, offering insights into PS development.

Area of Science:

  • Microbiome research
  • Immunology
  • Genetics

Background:

  • The link between gut microbiota and puerperal sepsis (PS) is not well understood.
  • The role of immune cells in mediating this relationship requires further investigation.

Purpose of the Study:

  • To investigate the causal relationship between gut microbiota and PS using Mendelian randomization (MR).
  • To assess the mediating role of immune cells in the development of PS.

Main Methods:

  • Utilized large-scale genome-wide association studies (GWAS) data for gut microbiota, immune cell phenotypes, and PS.
  • Employed univariate Mendelian randomization (UVMR) with inverse variance weighting (IVW) and sensitivity analyses.
  • Conducted two-step mediation Mendelian randomization (MR) analysis to explore mediation pathways.

Main Results:

  • Identified 11 gut microbial species with a causal association with PS, including Azorhizobiume and Bacillus velezensis.
  • Confirmed no reverse causality between PS and gut microbiota.
  • Found that IgD-CD27- B cells (10.26%) and CD62L- monocytes (17.29%) partially mediated the effect of CAG-245 sp000435175 on PS risk.

Conclusions:

  • Established a causal link between specific gut microbiota and PS.
  • Demonstrated a mediating role for certain immune cell populations in PS pathogenesis.
  • Findings may inform personalized PS treatments and biomarker development.
Keywords:
Gut microbiotaimmune cells.puerperal sepsis

More Related Videos

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.8K
A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.7K

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
83.6K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.6K
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
244
Relationship Formation02:12

Relationship Formation

What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
45.3K
Ending Relationships01:28

Ending Relationships

The dissolution of intimate relationships presents complex emotional and psychological challenges, particularly when emotional bonds are strong, the relationship is long-standing, and perceived alternatives are limited. This distress often intensifies in romantic breakups, where the initiator may experience greater turmoil than the rejected partner. Contributing factors include residual attachment, guilt over causing pain, and uncertainty about how to manage the situation. The stress is further...
178
Genetics of Speciation02:16

Genetics of Speciation

Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.0K