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Particle size distribution and concentration of Intralipid® 20.

Mona Shahsavari1,2,3,4, Martine Kuiper1,2,5, Mendel Engelaer1,2,3,4

  • 1University of Amsterdam, Amsterdam UMC, Biomedical Engineering & Physics, Amsterdam, The Netherlands.

Journal of Biomedical Optics
|January 26, 2026
PubMed
Summary

Accurate measurements of Intralipid® 20% particle properties confirm its reliability as a tissue-mimicking phantom. This supports its use in optical studies and calibration, ensuring precise results for biological tissue research.

Keywords:
Intralipid®anisotropy factorparticle size distributionphase functionrefractive indexscattering coefficient

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Area of Science:

  • Biomedical Optics
  • Materials Science
  • Nanotechnology

Background:

  • Intralipid® is a common tissue phantom due to its optical properties.
  • Accurate optical modeling requires detailed knowledge of phantom scatterer properties.

Purpose of the Study:

  • Determine particle size distribution (PSD), concentration, and refractive index (RI) of Intralipid® 20%.
  • Validate Intralipid® as a reliable phantom for optical studies.

Main Methods:

  • Utilized cryo-electron microscopy, flow cytometry, and microfluidic resistive pulse sensing.
  • Calculated particle volume fraction and compared with expected values.
  • Applied Mie theory to determine optical parameters (scattering, phase function, anisotropy, reduced scattering).

Main Results:

  • PSD spans 67 nm to over 2000 nm, with decreasing concentration at larger diameters.
  • Calculated particle volume fraction showed <2% deviation from the expected value.
  • Optical parameters agreed well with literature values and were described by empirical fits (R>0.97).

Conclusions:

  • Accurate characterization of Intralipid® 20% particle properties was achieved.
  • Validated Intralipid® 20% as a reliable tissue-mimicking phantom.
  • Supports the use of Intralipid® for optical studies and calibration.