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Production and Optimization of LTE, a Leishmania tarentolae Derived Cell-Free Protein Expression System for Recombinant Protein Production
Published on: November 8, 2024
The Advanced BioTRIZ Method Based on LTE and MPV
Zhonghang Bai1,2,3, Linyang Li1,3,4, Yufan Hao1,2,3
1National Engineering Research Center for Technological Innovation Method and Tool, Tianjin 300401, China.
Abstract:
While BioTRIZ is widely employed in biomimetic design to facilitate creative ideation and standardize workflows, accurately formulating domain conflicts and assessing design schemes during critical stages-such as initial concept development and scheme evaluation-remains a significant challenge. To address these issues, this study proposes an advanced BioTRIZ method. Firstly, the theory of technological evolution is integrated into the domain conflict identification stage, resulting in the development of a prompt framework based on patent analysis to guide large language models (LLMs) in verifying the laws of technological evolution (LTE). Building on these insights, domain conflicts encountered throughout the design process are formulated, and inventive principles with heuristic value, alongside standardized biological knowledge, are derived to generate conceptual solutions. Subsequently, a main parameter of value (MPV) model is constructed through mining user review data, and the evaluation of conceptual designs is systematically performed via the integration of orthogonal design and the fuzzy analytic hierarchy process to identify the optimal combination of component solutions. The optimization case study of a floor scrubber, along with the corresponding experimental results, demonstrates the efficacy and advancement of the proposed method. This study aims to reduce the operational difficulty associated with implementing BioTRIZ in product development processes, while simultaneously enhancing its accuracy.
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