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Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force.

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Mechanical Protein Function

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Related Experiment Video

Updated: Jan 28, 2026

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials

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Published on: June 25, 2018

Functional Peptide-Based Biomaterials for Pharmaceutical Application: Sequences, Mechanisms, and Optimization

Dedong Yu¹, Nari Han¹, Hyejeong Son¹

¹College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea.

Journal of Functional Biomaterials

|January 27, 2026

Summary

Peptide biomaterials offer precise, biocompatible drug delivery solutions. Advances in design and AI integration accelerate their clinical translation for enhanced pharmaceutical applications.

Keywords:

AI cell-penetrating peptide drug delivery peptide linker peptide-based biomaterials self-assembling peptide sequence design targeted delivery

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Area of Science:

Biomaterials Science
Pharmaceutical Sciences
Drug Delivery

Background:

Peptide-based biomaterials are promising for drug delivery due to biocompatibility and sequence tunability.
A comprehensive overview of their categories, mechanisms, and optimization is needed for clinical translation.

Purpose of the Study:

To systematically review advances in peptide-based biomaterials for drug delivery.
To cover categories, mechanisms, and optimization strategies for clinical translation.

Main Methods:

Systematic collation of advances in peptide-based biomaterials.
Categorization into peptide excipients, self-assembling peptides, and peptide linkers.
Dissection of sequence-based optimization strategies, including AI assistance.

Main Results:

Cell-penetrating peptides facilitate intracellular delivery.
Self-assembling peptides form nanostructures for controlled release.
Peptide linkers enable site-specific drug release, with optimization enhancing stability and targeting.

Conclusions:

Peptide-based biomaterials provide precise, biocompatible, and tunable drug delivery solutions.
AI-driven design and multi-functional modifications will accelerate clinical translation.