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Bioinformatic Analysis of Differentially Expressed Long Non-Coding RNAs in Skeletal Muscle Following Aerobic and
Kassia Régnier1, Lucas P R Beaupre1, Ian F Coccimiglio2,3
1School of Kinesiology and Health Studies, Queen's University, Kingston, ON K7L 3N6, Canada.
Genes
|January 28, 2026
Summary
Long non-coding RNAs (lncRNAs) show different expression patterns in skeletal muscle after aerobic exercise versus resistance exercise. These distinct lncRNA profiles suggest unique roles in muscle adaptation to various exercise types.
Area of Science:
- Molecular biology
- Exercise physiology
- Genomics
Background:
- Long non-coding RNAs (lncRNAs) are increasingly recognized for their role in cellular adaptive responses.
- The specific impact of different exercise modalities on lncRNA expression in skeletal muscle remains largely unexplored.
Purpose of the Study:
- To bioinformatically analyze and compare lncRNA expression profiles in skeletal muscle following acute aerobic exercise (AE) and resistance exercise (RE).
Main Methods:
- Utilized publicly available RNA-sequencing data.
- Performed differential expression analysis to identify significant lncRNA changes.
- Compared lncRNA profiles between AE and RE at baseline, 1 hour, and 4 hours post-exercise.
Main Results:
- Identified distinct lncRNA expression patterns between AE and RE.
- Observed time-dependent variations in lncRNA profiles post-exercise.
- These findings indicate exercise-modality-specific roles for lncRNAs in skeletal muscle.
Conclusions:
- lncRNA expression is differentially regulated by aerobic and resistance exercise in skeletal muscle.
- Specific lncRNAs likely play distinct roles in mediating the adaptive responses to different exercise types.
- Further research is warranted to elucidate the functional significance of these identified lncRNAs in exercise adaptation.
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