Related Experiment Video
Updated: Jan 29, 2026
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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
Published on: March 3, 2023
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Assessment of Oxidative Stress and Antioxidant Status in Allergic Rhinitis
Ahmet Burak Gürpınar1, Selen Karaoğlanoğlu2
1Department of Medical Biochemistry, Faculty of Medicine, Tokat Gaziosmanpaşa University, 60030 Tokat, Türkiye.
Biomedicines
|January 28, 2026
Summary
Allergic rhinitis patients show disrupted thiol-disulfide homeostasis and increased oxidative stress. These markers, including total thiol and native thiol, may help diagnose allergic rhinitis.
Area of Science:
- Immunology
- Biochemistry
Background:
- Allergic rhinitis (AR) is a chronic IgE-mediated inflammatory condition.
- Oxidative stress (OS) plays a significant role in AR.
- Thiol-disulfide homeostasis (TDH) is a key biochemical balance.
Purpose of the Study:
- To investigate dynamic TDH and OS markers in AR patients versus healthy controls.
- To assess the correlation between OS markers and laboratory parameters.
- To evaluate the diagnostic performance of OS markers in AR.
Main Methods:
- Enrolled 31 AR patients and 31 healthy controls.
- Measured hematological and biochemical parameters.
- Assessed OS markers: total thiol (TT), native thiol (NT), disulfide, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI).
- Performed correlation and ROC analyses.
Main Results:
- AR patients had lower TT and NT levels, and higher disulfide, disulfide/NT, disulfide/TT ratios, TOS, and OSI.
- TAS levels were slightly lower in AR patients.
- TT and NT correlated with eosinophils, monocytes, platelets, AST, and creatinine.
- ROC analysis showed diagnostic potential for TT, NT, and disulfide markers.
Conclusions:
- AR is associated with disrupted TDH and elevated OS.
- These OS markers can serve as sensitive indicators of oxidative imbalance in AR.
- Potential diagnostic and therapeutic insights for AR management were identified.
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